Biology, Reprogrammed.

CellRewire is building the operating system for programmable biology. We combine deep reinforcement learning, single-cell genomics, and autonomous wet-lab integration to make cellular reprogramming predictable, scalable, and clinically actionable.

Our platform models disease as a problem of cellular state — and treats it by designing the minimal molecular interventions needed to move cells back toward health.

Why We Exist

Biology has never been truly programmable. Decades of cell therapy research have been constrained by trial-and-error wet-lab cycles, opaque gene regulatory networks, and the inability to predict how cells will respond to interventions. CellRewire was founded to change that.

We believe that direct cellular reprogramming — converting one mature cell type into another without passing through a pluripotent state — is the safest, most scalable path to curative cell therapies. What has been missing is the AI infrastructure to design these conversions rationally. That is what we built.

The Platform

RewireOS is CellRewire's AI platform for direct cellular reprogramming. It integrates three core capabilities:

• Cell-DRL Agent — a deep reinforcement learning engine that reasons over single-cell transcriptomic data to reconstruct cellular state trajectories and propose minimal, targeted molecular switches.
• Gene Regulatory Network Modeling — high-resolution mapping of transcription factor networks that govern cell identity, enabling rational design of reprogramming factors.
• Autonomous Wet-Lab Integration (AutoLab) — closed-loop experimental workflows that validate AI predictions in real time, compressing the design-test-learn cycle from months to days.

Initial Programs

• Cardiac reprogramming (RewireMI, CR-101): fibroblast to cardiomyocyte conversion after myocardial injury.
• Parkinson's disease (RewirePD, NR-201): astrocyte to dopaminergic neuron reprogramming.
• Type 1 diabetes (RewireBeta, MT-301): endocrine or alpha-cell to beta-cell reprogramming.

Where We Operate